Petra de Haas was the inventor and lead the development of Simple One-Step (SOS) stool processing method for the detection of M. tuberculosis complex (MTBC) in stool. As a Laboratory Scientist, Petra has 34 years experience advising laboratories on the implementation of diagnostics and guidelines, training and mentoring laboratory staff, operational research projects, and developing National TB Program guidelines and national TB laboratory strategic plans.

Petra has published extensively, with over 70 articles published in peer reviewed journals and co-authored two books, and is an expert in Mycobacterium tuberculosis complex and nontuberculous mycobacteria, the design, implementation, analysis and reporting of operational research, Mycobacterium tuberculosis genotypes and mechanisms that influence drug resistance and virulence, TB Xpert systems, designing diagnostic algorithms, and the design, construction and operation of national TB laboratories. Petra assessed the laboratory network structure in Nigeria, Zambia and Indonesia as part of the Joint External Monitoring Mission (JEMM), and was TB Diagnostic Team Manager and lead a strategic research project on Mycobacterium tuberculosis drug resistance at the National Institute of Public Health and Environment (RIVM) in the Netherlands.

Within KNCV, Petra is engaged in this developed and execution of KNCV intervention pathways, and provides technical advice to National TB Programs on (BSL3) laboratory design and operations, national prevalence surveys for TB and nontuberculous mycobacterial, and the collection, testing, transport and storage of clinical samples. Petra also undertakes laboratory assessments, trains and mentors laboratory staff and develops laboratory guidelines, manuals, and standard operating manuals.

Recent Publications

1. de Keijzer J, Mulder A, de Haas PE, de Ru AH, Heerkens EM, Amaral L, van Soolingen D, van Veelen PA. Thioridazine Alters the Cell-Envelope Permeability of Mycobacterium tuberculosis. J Proteome Res. 2016 Jun 3;15(6):1776-86. doi: 10.1021/acs.jproteome.5b01037. Epub 2016 May 9.
2. Kapata N, Mbulo G, Cobelens F, de Haas P, Schaap A, Mwamba P, Mwanza W, Muvwimi M, Muyoyeta M, Moyo M, Mulenga L, Grobusch MP, Godfrey-Faussett P, Ayles H. The Second Zambian National Tuberculosis Drug Resistance survey – a comparison of conventional and molecular methods. Trop Med Int Health. 2015 Jul 30. doi: 10.1111/tmi.12581.
3. de Keijzer J, de Haas PE, de Ru AH, van Veelen PA, van Soolingen D Disclosure of selective advantages in the “modern” sublineage of the Mycobacterium tuberculosis Beijing genotype family by quantitative proteomics. Mol Cell Proteomics. 2014 Oct;13(10):2632-45.
4. Ayles H, Muyoyeta M, Du Toit E, Schaap A, Floyd S, Simwinga M, Shanaube K, Chishinga N, Bond V, Dunbar R, De Haas P, James A, Gey van Pittius NC, Claassens M, Fielding K, Fenty J, Sismanidis C, Hayes RJ, Beyers N, Godfrey-Faussett P; ZAMSTAR team., Effect of household and community interventions on the burden of tuberculosis in southern Africa: the ZAMSTAR community-randomised trial., 2013, Lancet. Oct 5;382(9899):1183-94
5. Huyen MN, Tiemersma EW, Kremer K, de Haas P, Lan NT, Buu TN, Sola C, Cobelens FG, van Soolingen D., Characterisation of Mycobacterium tuberculosis isolates lacking IS6110 in Viet Nam., 2013, Int J Tuberc Lung Dis. Nov;17(11):1479-85.

 

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